2. Signaling Pathways
  3. GPCR/G Protein
  4. TSH Receptor
  5. TSH Receptor Inhibitor

TSH Receptor Inhibitor

TSH Receptor Inhibitors (2):

Cat. No. Product Name Effect Purity
  • HY-P99165
    Teprotumumab
    		Inhibitor 99.45%
    Teprotumumab is an IGF-1 receptor (IGF-1R) blocking human monoclonal antibody. Teprotumumab binds to the ligand binding extracellular α-subunit domain of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab attenuates TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used for thyroid-associated ophthalmopathy research.
  • HY-129995
    TSHR antagonist S37b
    		Inhibitor 99.06%
    TSHR antagonist S37b is the less effective enantiomer of TSHR antagonist S37a (HY-129995A). TSHR antagonist S37b shows only a minor effect for thyrotropin receptor (TSHR) inhibition. TSHR antagonist S37b can be used for the research of thyroid function.